Do We Need These Omicron-Specific Boosters? (w/Dr. Paul Offit)

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By ZDoggMD LLC and Dr. Zubin Damania. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

A must-watch deep dive into some science!

Vaccine expert Dr. Paul Offit is less than impressed with evidence to support the Omicron BA.4/5 "bivalent" booster shots now rolling out for everyone 12 and older. We also talk polio and monkeypox and flu 👍

Video: https://zdoggmd.com/paul-offit-10/

Topics & Timestamps:

00:00 Intro

1:10 A brief history of the Covid vaccines, groups that benefit from boosting

5:12 Incubation periods and vaccination "goals," preventing infection vs. severe disease

10:54 Bivalent vaccine, the FDA's EUA approach, crucial dosing issues (ancestral strain vs. bivalent)

17:15 BA.4/5 booster immunogenicity data (or lack thereof), mouse data & vax safety profile

21:40 Why Paul himself would pass on the new booster, incubation periods, why Covid zero is a fantasy

24:28 Paul's "perfect" bivalent vaccine

25:37 Yearly targeted boosters, myocarditis and the Thai children's study

28:39 BA.4/5: MIS-C, boosters & long Covid, data from JAMA's Italian study

31:28 Comparing BA.4/5 & the yearly flu vax, timing of the yearly flu shot

38:45 Polio's resurgence, injected inactivated vs. live oral polio vaccines, the role of sanitation

48:05 Monkeypox and a history of smallpox vaccines

56:43 Reflection w/Dr. Offit: what he's gotten right, what he's gotten wrong and where to go from here

1:01:57 Final thoughts

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692 episodes