How to Slow Down Your Biological Aging – Morgan Levine, Ph.D. : 941

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.

We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan.

“If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says.

She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging.

She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.

Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly.

This conversation gets into topics and makes them make sense for your own aging, like:

  • Epigenetics & epigenetic clocks
  • DNA methylation & telomeres
  • Cell lifespan
  • Ageotypes (molecular assessment of aging)
  • Phenotypic age
  • The “Ceiling” effect
  • The “CALERIE” trial
  • Nutrition & aging (plants, fasting, ketosis)
  • Fitness & aging (energy & brain health)
  • Rest & relaxation (sleep & biological programming)

Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking.

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