Talking BFR, ACLR and Muscle with Brian Noehren, PT, PhD and Chris Fry, PhD

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In this episode we chat with Associate Professor in the Division of Physical Therapy and the Department of Orthopedic Surgery at University of Kentucky Brian Noehren, PT, PhD, FACSM and Associate Professor Chris Fry, PhD of University of Kentucky in the Department of Athletic Training and Clinical Nutrition. Brian and Chris have a registered (ref. no. NCT03364647), ongoing ACLR trial utilizing BFR where they will be taking serial biopsies to exam what effect the intervention is having upon the quality of the muscle; something they’ve identified to be problematic in previous studies. Here’s a link to their study protocol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665950/ The articles we discussed in this episode: Noehren, B., Andersen, A., Hardy, P., Johnson, D. L., Ireland, M. L., Thompson, K. L., & Damon, B. (2016). Cellular and Morphological Alterations in the Vastus Lateralis Muscle as the Result of ACL Injury and Reconstruction. The Journal of Bone and Joint Surgery. American Volume, 98(18), 1541–1547. Peck, B. D., Brightwell, C. R., Johnson, D. L., Ireland, M. L., Noehren, B., & Fry, C. S. (2019). Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality. The American Journal of Sports Medicine, 363546519832864. Noehren, B., & Snyder-Mackler, L. (2020). Who’s Afraid of the Big Bad Wolf? Open-Chain Exercises After Anterior Cruciate Ligament Reconstruction. The Journal of Orthopaedic and Sports Physical Therapy, 50(9), 473–475. Moro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019). Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. Experimental Gerontology, 127, 110723. Nielsen, J. L., Aagaard, P., Bech, R. D., Nygaard, T., Hvid, L. G., Wernbom, M., Suetta, C., & Frandsen, U. (2012). Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. The Journal of Physiology, 590(17), 4351–4361. If you’d be interested in pursuing a PhD with these gentlemen feel free to reach out at: b.noehren@uky.edu christopher.fry@uky.edu Or, find Brian and Chris on Twitter: @bnoehren @ChrisFryPhD

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