LSD & Psychedelic Chemistry

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By Alex Dorr and Lera Niemackl, Alex Dorr, and Lera Niemackl. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

Lysergic acid diethylamide (LSD) is one of fungi’s most well known chemical analogues. Today we bring you a leading scientist, Dr. David Nichols who speaks to the history, chemistry, legality and so much more of this notable compound.

Topics covered:

  • David Nichol’s career pursuing psychedelic pharmacology
  • Patent litigation, especially with psychedelic constituents
  • Lab testing for new psychedelic analogues in rats
  • Bureaucracy of working with Schedule I substances
  • How to synthesize LSD
  • LSD’s physical characteristics, structure and fluorescence
  • What happens to the LSD molecule when you adjust minute aspects, and what that tells us about itself
  • Structural similarities and differences in an array of psychedelic molecules / chemical ‘templates’ for psychoactive compounds
  • Neuro-mechanics of LSD and other entheogenic compounds
  • Evolution and function of serotonin receptors
  • HPPD: Hallucinogen Persisting Perception Disorder
  • Trepanation: how does it affect neurochemistry, if at all?
  • NBOMes (N-benzyl methoxy): What is it and how does it work?
  • Metabolizing LSD and related compounds
  • Chirality in psychedelics, especially LSD
  • Listener questions

Show notes:

Hamilton’s Pharmacopeia feat. Dr. Nichols: https://www.youtube.com/watch?v=7N4VoqeuK3s

Hallucinogens (2004) : https://pubmed.ncbi.nlm.nih.gov/14761703/

DEA 222 - https://dehs.umn.edu/using-dea-form-222-order-controlled-substances

Mapping the Mind Talk: https://www.youtube.com/watch?v=6hfsIbib_50

MAPS Talk: https://www.youtube.com/watch?v=TxjCSKMbZBA

Telluride Keynote presentation: https://www.youtube.com/watch?v=RlDCM5JQzRk

Leo Perutz & the Mystery of St Peter’s Snow: https://www.tandfonline.com/doi/abs/10.2752/175169713X13589680082172

Trepanation articles & video: https://lostmediawiki.com/Heartbeat_in_the_Brain_(partially_found_Amanda_Fielding_trepanation_documentary;_1970)

Downloadable literature: https://drive.google.com/drive/folders/14N9VdXGFlLvjnShYRH2MRurNi54a77Ig?usp=sharing


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