#062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks


Manage episode 300075139 series 2705056
By Rhonda Patrick, Ph.D. and Rhonda Patrick. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

Steve Horvath

Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health

Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

In this episode, we discuss:

  • 00:00 - Introduction and overview
  • 20:24 - Horvath Aging Clocks
  • 26:36 - Heredity determines aging
  • 35:49 - DNAm PhenoAge vs GrimAge
  • 45:58 - Slowing the epigenetic clock
  • 01:10:43 - Epigenetics: Cause or consequence of aging?
  • 01:16:43 - Vitamin D reverses epigenetic age
  • 01:19:07 - Omega-3 slows GrimAge clock
  • 01:24:19 - Ongoing research

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath

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129 episodes