Antidepressants and Psychedelics: Comparisons, Contrasts, and Combinations | Benjamin Malcolm, The Spirit Pharmacist ~ ATTMind 140


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Benjamin Malcolm, aka The Spirit Pharmacist, joins us on to explore and compare the pharmacological actions of antidepressant psychotropics with the actions of the classical psychedelics, ayahuasca, MDMA, and ketamine.

We also explore the risk of combining psychedelics, MDMA, and/or ketamine with the different classes of antidepressants, including SSRIs, SNRIs, and MAOIs, and even NDRIs like Wellbutrin and Strattera.

This episode is chock full of very specific information about pharmacology. Get your notepad ready.


For links to Malcolms's work, full show notes, and to watch this episode in video, head to ***Full Topics Breakdown Below*** SUPPORT THIS PODCAST ► Patreon: ► Donations: ► Merchandise: ► More options: ► Newsletter: *** Extra BIG thanks to my patrons on Patreon for helping keep this podcast alive! Especially, Andreas D, Clea S, Joe A, Ian C, David WB, Yvette FC, Ann-Madeleine, Dima B, Eliz C, Chuck W, Nathan B, Nick M, & Wes p Episode Breakdown
  • The difference between antidepressants and psychedelics as treatments for mental health disorders
  • How antidepressant psychotropics address mental health disorders
  • How psychedelics address mental health disorders
  • Psychedelic psychotherapy is suffering under the weight of trying to fit in with psychiatry
  • Psychedelics help you heal yourself, by helping to heal your brain
  • How the classical psychedelics affect the brain—Lsd, psilocybin, MDMA, Ayahuasca, and Ketamine
  • Neurotrophic factors and psychedelic induced neuroplasticity
  • Combining tricyclic antidepressants and psychedelics (including MDMA, ketamine, and ayahuasca)
  • What are MAOIs (a vs b, reversible vs irreversible) and their interaction with psychedelics (and ayahuasca)
  • An explanation of serotonin syndrome
  • Combining MAOIs with psilocybin and LSD
  • Combining MAOIs with MDMA (as well as other stimulants)
  • SRI’s and SNRI’s— what are they and how do they interact with psychedelics
  • SSRIs reduce the effects of MDMA
  • Is it a good idea to use Prozac for MDMA hangover
  • NRI and NDRI–what are they and how do they interact with psychedelics (including ayahuasca)
  • Mixing Wellbutrin or Straterra with psychedelics
  • Why anecdotal evidence for drug reactions doesn't amount to much
  • Combining SARI (trazodone) with psychedelics
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170 episodes