Precept2practice Podcasts

Osteoporosis may be a forgotten disease – common but rarely treated. The 2023 guidelines are not here. Join host, Geoff Wall, as he reviews the new treatment recommendations and how we can optimize pharmacotherapy for all persons with osteoporosis. The GameChanger Osteoporosis is common and routine screenings should be implemented. Bisphosphonates …

Hydrochlorothiazide is the go-to thiazide for hypertension control despite better data for chlorthalidone. Join host Geoff Wall as he evaluates the new randomized controlled study to determine what is the best thiazide. The GameChanger Several pharmacologic differences exist between hydrochlorothiazide and chlorthalidone. The new DCP Study did not …

Results from early COVID-19 studies are still emerging. Some micronutrients, such as zinc, have been shown to decrease the severity of viral infections yet human data is sparse. Join host, Geoff Wall, as he evaluates a new study looking at the proposed benefit of zinc in COVID-19 infections. The GameChanger Zinc has several antiviral properties. A …

Sometimes teaching isn't "telling" but "asking" - asking questions that encourage students and residents to problem-solve in a stepwise manner. Listen in as we discuss a teaching strategy that builds confidence and encourages curiosity in your learners. We’ve all heard students and residents complain about ‘pimping’ from preceptors during rotations…

Celiac disease is of the most common auto-immune diseases in the world. The only current treatment is maintaining a strict gluten-free diet. Join host, Geoff Wall, as he discusses the results of a phase 2 study investigating a novel pharmacologic treatment of Celiac disease. The GameChanger Celiac disease is common and has a myriad of symptoms. A n…

The American Diabetes Association Standards of Care in Diabetes are a “living” guideline – the recommendations are updated throughout the year and major revisions occur in January. In this episode, guest host, Jake Galdo, is joined by Susan Cornell as they evaluate new pharmacotherapy recommendations in the ADA Standards of Care. The GameChanger Tr…

Stimulant medications, like methylphenidate and amphetamines, have adverse cardiovascular effects, like elevated blood pressure, increasing the risk of cardiovascular events. Join host Geoff Wall as he reviews a new meta-analysis trying to quantify the risk of ADHD medications on cardiovascular outcomes. The GameChanger A large meta-analysis did no…

COPD is a common and complex disease for both inpatient and outpatient providers. GOLD guidelines provide diagnosis and treatment recommendations for COPD and were recently updated. Join host Geoff Wall as he breaks down the salient recommendations in the 2023 GOLD guidelines. The GameChanger A new severity scoring system for COPD exists – category…

We’ve heard a lot about microaggressions in the past couple of years. A microaggression can include verbal, behavioral, or environmental aggressions that negatively communicate about race, culture, or gender. They can be intentional or unintentional but can negatively impact healthcare interactions – whether those involve students, residents, patie…

Gabapentin is often used in a multi-model pain management strategy in both peri- and post-operative setting. Little data exists looking at the adverse effects of this practice. Join host Geoff Wall, as he reviews data from a new study looking at this question. The GameChanger Gabapentin’s data is sparse for use in postoperative pain; however, new d…

The standard of care for pancreatitis has been aggressive (liters) of intravenous fluids. New data suggests that this level of fluid resuscitation may not be needed – and possibly harmful. Join host Geoff Wall as he evaluates the role of fluids in pancreatitis treatment. The GameChanger In patients with mild disease, moderate fluid resuscitation is…

A recent study showed that ethanol abuse is a leading cause of death in young adults in the US and that rates of alcoholism have increased. Join host Geoff Wall as he reviews the treatment of ethanol withdrawal. The GameChanger Ethanol abuse is a leading cause of death in young adults. Fortunately, multiple therapies exist to treat hospitalized pat…

Obesity is still at epidemic levels in the United States. More and more medications are coming to market to help with weight loss. The American Gastroenterological Association (AGA) just released guidelines for evidence-based care for persons with obesity. The GameChanger Guidelines are now available for the treatment of obesity. The evidence-based…

Health Equity is achieved when every person has the opportunity to attain their full health potential and no one is disadvantaged. Oftentimes, this is evaluated and addressed through resolving social determinants of health. A recent study evaluated the impact of food insecurity on cardiovascular outcomes. Join host, Geoff Wall, as he discusses how …

Whose job is it to teach risk management principles to pharmacy learners? Sure – they have to take a law course as part of their curricular requirements, but how much does that mean to them until they are in real life situations as part of their IPPEs, APPEs, or residency? As preceptors, it’s important that we not only recognize and manage the lega…

Various SGLT-2s have been shown to improve cardiovascular outcomes in the presence and absence of diabetes. A recent study evaluated the effect of dapagliflozin in mildly reduced or preserved ejection fraction. Join host, Geoff Wall, as he discusses how SGLT-2s may be a real GameChanger in heart failure with expert, Troy Lynn Lewis. The GameChanger…

Less than ten percent of people filled a glucagon prescription after a hospitalization due to hypoglycemia. In the past few years, a slew of new glucagon products have come to market. Join host, Geoff Wall, as he discusses how to optimize glucagon therapy with diabetes expert, Jamie Pitlick. The GameChanger Despite glucagon products being proven sa…

The GRADE studies evaluated the pharmacotherapy of diabetes after initiation of metformin – for both micro- and macrovascular outcomes. Join host, Geoff Wall, and guest Jake Galdo as they examine these studies to determine if they are GameChangers in diabetes management. The GameChanger Insulin glargine and liraglutide had the biggest decrease in A…

The role of anticoagulant therapy (warfarin) with antiplatelet therapy (aspirin) is a balance of risk versus benefit. However, reducing risk by de-prescribing is often avoided due to hypothetical efficacy reduction. Join host, Geoff Wall, as he evaluates de-prescribing aspirin in patients taking anticoagulants. The GameChanger Anticoagulant therapy…

So often, we can fall into the trap of viewing our time with experiential learners as a burden – something that takes time and energy that we feel we don’t have in a busy practice. How can you operationalize and optimize student contribution on-site, build trust among all parties, and overcome challenges and barriers that come along with experienti…

Studies suggest that patients admitted to the hospital with heart failure are inadequately diuresed before discharge. Join host, Geoff Wall, as he reviews the data on acetazolamide for diuresis in heart failure. The GameChanger Augmentation of loop diuretics with acetazolamide significantly increases diuresis in persons with heart failure. Geoff pr…

The current standard of care is to provide a bolus of 30 mL per kg of isotonic fluid for patients with septic shock. Recent retrospective studies question this practice. Join host, Geoff Wall, as he reviewed a NEJM article on the role of fluids in septic shock. The GameChanger Large boluses of fluid during septic shock may have unintended adverse e…

Get FREE CE for this episode by downloading the CEimpact App (details in the FREE CE section). The current reality of COVID-19 is reviewed in this episode by Dr. Katelyn Jetelina. Dr. Jetelina is an epidemiologist and author of the wildly popular Newsletter, Your Local Epidemiologist, available via Substack. We are losing ~400 Americans a day. Duri…

Monkeypox is the newest worldwide pandemic and closely mirrors both COVID-19 and HIV pandemics. A large difference is theoretical vaccines and treatments for monkeypox already exist. In this episode of GameChangers, host Geoff Wall, evaluates tecovirimat, a potential monkeypox treatment and the regulations that made it possible. The GameChanger Lit…

Pharmacogenomic testing has been widely available for over a decade to help guide pharmacotherapy including antidepressant selection when treating major depressive disorder. Yet, the data hasn’t substantiated improved safety or efficacy. Host Geoff Wall is joined by Sarah Grady, PharmD to evaluate the PRIME study looking at the role of pharmacogeno…

Studies have connected racial and cultural bias in students and how they approach patient cases in their respective PharmD curriculum. How can preceptors identify and address potential bias in pharmacy learners to help ensure healthcare equity? Host Kathy Schott, PhD CEimpact Guest LaQuoia Johnson, PharmD, BCPS, DPLA Pharmacy Consultant Growing Thr…

The GINA guidelines were updated in 2021, yet providers may not have rolled out the recent changes in practice. JAMA Clinical Guidelines Synopsis highlighted the major recommendations, including SMART therapy (single maintenance and reliever therapy) with an “A” recommendation. Join host Geoff Wall as he talks about implementing new recommendations…

High-Intensity Statins have been the treatment of choice for ASCVD. However, the recent non-inferiority RACING study evaluates the role of combination moderate-dose statin plus ezetimibe to high-dose statin in ASCVD. Host Geoff Wall breaks down another potential GameChanger in Pharmacotherapy. The GameChanger Combination moderate-dose statins plus …

Vaccine distrust and misinformation is at an all-time high. One claim is that vaccines are responsible for dementias, like Alzheimer’s Disease. A recent database study may show the exact opposite. Join host, Geoff Wall, with guest, Jake Galdo, to discuss the role of vaccines and other therapies in the prevention of Alzheimer’s Disease. The GameChan…

Insomnia is a common medical condition treated with a variety of pharmacologic (Rx or OTC) and non-pharmacologic options. Yet, little data exist on long-term efficacy and safety on these treatment options. Join host Geoff Wall as he discusses a recent meta-analysis comparing treatments for insomnia. The GameChanger All treatments for insomnia, incl…

Irritable Bowel Syndrome (IBS) is a common disorder that greatly affects quality of life. Several medications have been approved for use in IBS – both constipation (IBS-C) and diarrhea (IBS-D). The American Gastroenterological Association just released guidelines provide evidence-based recommendations for patients. The GameChanger In the last 10 ye…

The United States Preventative Services Task Force issued new recommendations for the use of vitamins, minerals, and multivitamins for the prevention of cardiovascular disease and cancer. This is a revision from the 2014 recommendations and is based on recent data. Host Geoff Wall will provide a review of the recommendations – and evidence on these…

Calculating an accurate renal function in patients is crucial to ensure the right dose gets to the right patient. Previous equations to estimate glomerular filtration rate depended on a race variable. However, recent data suggests this underestimates the risk of chronic kidney disease in black patients. In this episode, host Geoff Wall discusses di…

A NON-endemic spread of monkeypox has been reported in multiple countries – a phenomenon that has never happened before. The Centers for Disease Control and Prevention and the World Health Organization are developing plans for potential outbreaks – what are the 101s on this disease for healthcare providers? The GameChanger Most cases of monkeypox a…

Several large observational studies have suggested metformin has anti-tumor effects and may be beneficial as an adjunctive treatment option for breast cancer. This hypothesis was tested by a randomized clinical trial recently published. Listen to host Geoff Wall discuss if metformin is a miracle drug. The GameChanger Metformin can alter insulin sig…

Nirmatrelvir-Ritonavir continues to be recommended for outpatient treatment of COVID-19 infections, especially as cases continue to rise. However, this therapy does present clinical challenges – from drug interactions to off-label dosing and rebound COVID-19 infections, therapy is not as easy as it sounds. Listen as host Geoff Wall describes the cl…

Curious about tirzepatide and what it means for patients? Tirzepatide, a combination GLP-1 and GIP agonist, was just approved by the Food and Drug Administration for the treatment of diabetes. Tirzepatide has also gained attention for its weight-reducing effects. However, how does tirzepatide compare to other GLP-1 agonists? Is tirzepaide a GameCha…

They are finally here! COVID-19 vaccines for children as young as 6 months. The FDA’s advisory committee unanimously voted to authorize vaccines from Pfizer & BioNTech and Moderna. But now the question, which one is best? *Note, per the PREP Act, pharmacists, pharmacy technicians, and pharmacy interns may administer COVID-19 vaccines to individuals…

Adequate risk assessment and management are crucial in preventing cardiovascular disease. A recent study examined the correlation between common measures of cholesterol concentration versus the number of apolipoprotein B (apo-B)-containing lipoproteins. In other words, should clinicians use different biomarkers for cardiovascular risk assessment? C…

Transgender individuals are more likely to receive unequal care and are less likely in general to seek care or preventative services. Often, they are even relied upon to educate their own providers on the basic tenets of transgender care. Healthcare providers can better serve these patients through an interprofessional approach to comprehensive, re…

The Centers for Disease Control and Prevention just updated guidelines for sexually transmitted infections (previously sexually transmitted diseases) for everything by HIV. In this multi-part series, host Geoff Wall will break down what’s new and what’s changing in practice. The GameChanger A 7-day course of doxycycline in the treatment of urogenit…

Twitter for educational purposes? Actually, yes! Listen in to hear how Timothy Gauthier, a social media savvy pharmacist and educator, uses social media in pharmacy education and professional development, and how you and your students can use it as a lifelong learning tool. Host: Kathy Schott, PhD CEimpact Guests: Timothy Gauthier, PharmD, BCPS, BC…

The CDC defines a Community Health Worker (CHW) as a frontline public health worker who is a trusted member of their community and/or has a thorough understanding of the community being served. Who would be better to fill this role than the Pharmacy Support staff! Training Pharmacy Technicians and other Pharmacy Support Staff as Community Health Wo…

The Centers for Disease Control and Prevention just updated guidelines for sexually transmitted infections (previously sexually transmitted diseases) for everything by HIV. In this multi-part series, host Geoff Wall will break down what’s new and what’s changing in practice. The GameChanger NAAT testing is the standard of care for genital herpes, a…

The Centers for Disease Control and Prevention just updated guidelines for sexually transmitted infections (previously sexually transmitted diseases) for everything but HIV. In this multi-part series, host Geoff Wall will break down what’s new and what’s changing in practice. The GameChanger Maintenace treatment for recurrent vulvovaginal candidias…

A recent study evaluated the role of metformin in causing birth defects, but when the men are prescribed metformin. This obstetrics study evaluates the role of the partner in risk for birth defects. Does the study change practice? Listen as host Geoff Wall discusses how pregnancy involves both partners. The GameChanger Emerging data suggest that ma…

A low salt diet can be difficult to maintain, especially in the United States. Multiple guidelines and decades of practice have suggested dietary limitation of sodium for patients with heart failure as an essential lifestyle modification. The recently published SODIUM-HF study evaluates this recommendation and enhances the data. The GameChanger Whi…

A nurse was found guilty of gross neglect and negligent homicide in Tennessee. This case has been closely watched by medical professionals, because it may set a new precedent for criminalizing medical mistakes. Guests David Brushwood and Jake Galdo join the podcast to try and make sense of this sensational news. The GameChanger: This case may chang…

Reliever Inhaled Glucocorticoid Treatment Black and Latinx patients are disproportionately impacted by asthma. In fact, asthma mortality rates are twice as high in Black patients compared to White patients. Are there different treatment options to help improve mortality in these populations? Join host Geoff Wall with guest Dr. Matt Trump as they di…

Septic shock is one of the most common causes of deaths in critically ill patients. The updated Surviving Sepsis Campaign Guidelines provide recommendations on the use of adjunct steroids in the treatment of sepsis. However, when to start corticosteroids is still unknown – or is it? This episode of GameChangers evaluates the timing of corticosteroi…