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Chorioamnionitis is an intrauterine infection of the placenta and fetal membranes. It is the leading cause of preterm delivery and is a common risk factor for adverse pulmonary outcomes such as bronchopulmonary dysplasia. There is evidence to suggest that the first negative impacts on pulmonary development occur in utero in the presence of chorioam…
 
Chorioamnionitis is an intrauterine infection of the placenta and fetal membranes. It is the leading cause of preterm delivery and is a common risk factor for adverse pulmonary outcomes such as bronchopulmonary dysplasia. There is evidence to suggest that the first negative impacts on pulmonary development occur in utero in the presence of chorioam…
 
So what is fly strike, what causes it and how can it be prevented and what do we do to treat it? Join Vet Dr Tim Gole from For Flock Sake (www.forflocksake.,com.au), a sheep consulting business as we explore the parasite paradise that fly strike is. Contact Tim: @for flock sake www.forflocksake.com.au Transcript: Parasite Paradise for flies It's pe…
 
The prognostic significance of regression has long been a matter of debate. Our guest, Professor Richard Scolyer, co-director of the Melanoma Institute Australia discussed his team’s recent findings on the prognostic value of regression, and the presence of regression and/or tumor infiltrating lymphocytes (TIL) in primary cutaneous melanomas predic…
 
Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory joint diseases in children. Previous studies have shown that in the oligoarticular subtype of this disease, T cells play a central role in pathogenesis. T cell inhibitory receptors (IRs) seem to play an important role in the development of tolerance and recognition of self a…
 
Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory joint diseases in children. Previous studies have shown that in the oligoarticular subtype of this disease, T cells play a central role in pathogenesis. T cell inhibitory receptors (IRs) seem to play an important role in the development of tolerance and recognition of self a…
 
Loneliness is a subjective experience, but neuroscientists define it as a distress that arrives from a discrepancy between perceived and desired social relationships. There may be an evolutionary benefit to the feeling of loneliness; we’re a social species, and feeling lonely might have sent us to seek out other humans, which has been very importan…
 
Congenital anomalies (CA), developmental delay (DD), and intellectual disability (ID) are among the most common indicators in children that lead to genetic testing. Identification of an underlying diagnosis for CA or DD/ID can be consequential to care management and long-term prognosis for the child. But there has been no evidence-based guideline f…
 
Dr. Sabina Berezowka, from the university of Lausanne Switzerland, discusses with our host her team’s recent study describing a novel “Prognostic Score” for assessing tumor regression following Neaodjuvant therapy in non-small cell lung cancer (NSCLC). The proposed combined prognostic score (PRSC) performed better than pTNM staging and previously p…
 
Dr. Jason Hornick discusses his team recent study finding that a monoclonal antibody directed against the N-terminus of DDIT3 is a highly sensitive and specific for high-grade MLPS. DDIT3 immunostains could replace molecular genetic testing in many cases, although limited labeling may be seen in a range of other tumor types.…
 
Bloat in bottle fed lambs is one of the most horrible things I have had to deal with in my shepherding experience. You have a really close relationship with animals that you bottle raise and losing them suddenly is heart breaking for us but imagine the pain the poor lamb must be in with bloat. So in this episode I am so grateful to Sez the Vet for …
 
Always a visionary, Dr. Reuter was one of the earliest Anatomic Pathologists to embrace and advance the genomic and more recently the digital transformation of our field.In this episode of Meet The Expert series, Dr. Reuter shares his perspective and vision on the current and future impact of digital pathology.…
 
In this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH assays can improve the accuracy and efficiency of MiTF-RCC diagnosis.Associated article: TRIM63 is a …
 
Dr. Clare Verrill and Andrea Chatrian of Oxford University in England discuss their team’s study on AI for advance ordering of IHC in difficult prostate biopsy. Their elegant work shows that an AI tool making automated IHC request prior to the pathologist read of H&E could create leaner workflow and result in pathologist time savings and shorten ov…
 
Dr. Britta Weigelt of MSKCC discusses her team’s study on synchronous endometrial (EC) and ovarian carcinomas (OC) in Lynch syndrome and constitutional Mismatch Repair Deficiency Syndrome (CMMRD). Contrary to sporadic synchronous ECs/OCs, which are almost invariably clonally related, ECs/OCs simultaneously involving the uterus and ovary in LS patie…
 
Red sea bream are an important fish in Japan, for both culinary and cultural reasons. But there’s a problem: transparent fish are appearing in fish farms! Join Dr Eitaro Sawayama (Nihon University) and find out how he uncovered the causative gene for this deformity, and what his work means for red sea bream aquaculture. Associated article: Identifi…
 
After more than 150 years, wolves once again roam the Germany countryside! Of course, a lot has changed in that time. Join Anne Jarausch (Senckenberg Research Institute and Natural History Museum Frankfurt) as she discusses her recent work looking at the genetics of this ongoing, rapid and natural wolf recolonisation.Associated article: How the wes…
 
Join us as we talk to the newest member of the Heredity editorial board: Prof. Sam Banks (Charles Darwin University). Discover his eclectic research tastes, hear about his recent Heredity paper on Australia’s threatened brush-tailed rabbit-rat, and be inspired by his passion for population genetics and ecology. Associated article: Population genomi…
 
Identifying the underlying genetic cause of kidney failure in patients awaiting transplant can impact donor choice and lead to changes in management and treatment. On this month’s GenePod, Eva Schrezenmeier at Charité-Universitätsmedizin Berlin and Carsten Bergmann at Medizinische Genetik Mainz and University Hospital Freiburg, discuss how genetic …
 
Previous studies have shown an association between fluid retention during the early postnatal period and increased BPD. However, these studies were performed nearly two decades ago meaning their results may not apply to the contemporary NICU setting, with its widespread use of surfactants and modern incubators. In this episode we meet this month's …
 
Respiratory support plays a crucial role in the care of preterm infants in the NICU, ensuring that they get enough oxygen during this critical period of development. But it is becoming increasingly clear that former preterm infants who have been exposed to ventilatory support are at an increased risk of developing asthma and other respiratory disor…
 
Previous studies have shown an association between fluid retention during the early postnatal period and increased BPD. However, these studies were performed nearly two decades ago meaning their results may not apply to the contemporary NICU setting, with its widespread use of surfactants and modern incubators. In this episode we meet this month's …
 
It’s known that dopamine transmission in the brain, particularly in the frontal lobes, can affect decision-making and can regulate choices when it comes to actions and rewards. But the effect of dopamine transition in the medial orbital frontal cortex hasn’t yet been studied, and dysfunction in that region has been implicated in a variety of mental…
 
While Fragile X syndrome is the most common cause of inherited intellectual disability, it is still underdiagnosed in the general population. As the phenotype may be subtle, the diagnostic pathway can take years. In addition to this, the syndrome is accompanied by many secondary health conditions — the full spectrum of which are not entirely unders…
 
So what is rumen acidosis? What causes it? What are the signs and what can you you do about it. Enjoy this last episode of season 2! What is acidosis? Grain overload (acidosis, grain poisoning) occurs when cattle, sheep or goats eat large amounts of grain. The grain releases carbohydrate into the animal's rumen and this rapidly ferments rather than…
 
Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene panel and MSI analysis and IHC for TP53, the author and her team revealed high rate of TP53 mutations and ga…
 
Dr. Stuart Schnitt from Brigham and Women Hospital in Boston discusses his team's recent findings of variable architectural and cytological patterns of residual disease in breast cancer patients with incomplete pathologic response. The relationship of pattern of residual disease to pre-treatment clinicopathologic parameters and the potential impact…
 
A scourge to many in agriculture, flour beetles in the genus Tribolium may be the best model system you’re not using. Join PhD student Michael Pointer, Prof. Matthew Gage and Dr Lewis Spurgin (University of East Anglia) as they discuss the importance of Tribolium beetles across a remarkable range of research fields… and their great untapped potenti…
 
Universal newborn screening has been successful at improving treatment and decreasing morbidity and mortality for a number of childhood diseases. Recently, a team of researchers investigated the utility of newborn screening for rare genetic pediatric cancer syndromes. Knowing whether a newborn has a genetic variant strongly associated with pediatri…
 
Respiratory support plays a crucial role in the care of preterm infants in the NICU, ensuring that they get enough oxygen during this critical period of development. But it is becoming increasingly clear that former preterm infants who have been exposed to ventilatory support are at an increased risk of developing asthma and other respiratory disor…
 
So much is said about sheep and minerals but what really matters most? In this episode Stefanie Hildmann from https://stefaniehildmann.com/ helps us to get a handle on the most important things and what we can do to help our sheep be as naturally healthy as possible. In this episode we explore: The difference between vitamins and minerals and macro…
 
Nearly 25 years ago, a paper was published about addiction that transformed the field. The director of the US National Institute on Drug Abuse at the time called addiction a “brain disease,” and he wrote a paper articulating this position and the agenda that it implied. It led to a focus on researching the brain to understand the mechanisms behind …
 
Enjoy this chat with Gary and I as we explore who our mentors are, what to expect from a mentor, how to find them and how to get the best from a relationship with your mentor. Some of the mentors mentioned include: Gabe Brown Greg Judy Joel Salatin Pay Colby William Albecht Gerhard Grasser Jason O'Loghlin Gavin Wall Check them out online via YouTub…
 
Extremely preterm infants are at a high risk for brain injury, and this risk is most severe in children with intraventricular hemorrhage followed by post-hemorrhagic ventricular dilation. Bedside cranial ultrasound allows clinicians to identify the progressive dilation of the lateral ventricles, however, there is currently no consensus on how to qu…
 
Lambing is the most important time of the shepherd's year. The sheep's, too. So, it's important to be prepared. Preparations include managing and feeding the sheep properly, getting the lambing facilities ready, and gathering necessary supplies. Preparing the Ewes Feeding and management during late gestation can determine success of the lambing sea…
 
All too often, genomic testing in patients with undiagnosed disorders results in the finding of variants of unknown significance (VUS). This leaves the health-care provider and patient in a quandary, not knowing whether that variant is disease causing or not. On this month’s GenePod, Bekim Sadikovic, PhD, director of the Clinical Genomic Center and…
 
Join Simon Makeham from North South Border Leicester Stud, a veteran sheep showing expert in this celebratory 50th episode of The Sheep Show Podcast! Simon shares some of the secrets to showing sheep, how to prepare your sheep and some ring craft tips for us to consider. In this episode we explore: What is the reason for the North South business co…
 
If you plan on showing your sheep then teaching your sheep to lead will be very helpful. Start off by purchasing a good quality Halter and lead rope, we use the following Halter which can be purchased online from The Farm Store. This halter is great as it can be adjusted both behind the poll and over the nose. | www.thefarmstore.com.au Bainbridge h…
 
For those new to showing or those who are thinking of showing in the new future I've put together my top dos and don'ts many of which I have learned the hard way! Let's start with the positives! Do · come ready to learn, meet new friends collaborate and ask questions. Being part of a show is very collegiate. We all help where we can, sharing advice…
 
So what are the different cuts of lamb? · There are nine basic or primal cuts from different parts of the lamb. · Each of these Primal cuts can be cut up different ways. · For example, the loin primal cut can be made into o Individual cutlets or o French rack or o Barbeque rack or o Backstraps · You can select either of these options but only one o…
 
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