show episodes
 
Here at Drug Discovery World (DDW) we've been publishing articles written by leading experts in the Drug Discovery, Pharmaceutical, and BioPharmaceutical industries for over 20 years. DDW has grown as a quarterly business review of drug discovery and development, and now we've created this podcast to allow you to listen to our articles on the go. In our journal and this podcast, we cover topics surrounding: drug discovery; drug development; business; chemistry; enabling technologies; informa ...
 
The BC Platforms podcast series, ‘From data to health’ brings together innovators representing the ecosystem of users, custodians, contributors of healthcare data. This series is hosted by Dr. Tonu Esko, head of the Estonian Biobank Innovation Center. Each guest sheds light on how they advance and envision the future of health through data.
 
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show series
 
This is the latest episode of the free DDW podcast: “Opportunities to improve drug discovery systems”. It covers two articles written for Volume 22, Issue 1 – Winter 2020/21 of the Drug Discovery World Magazine. The first article is titled “Precision control of protein release to reconfigure bioprocessing and cell-based assays”, where the authors D…
 
This is the latest episode of the free DDW podcast, “Putting virology back on the map: the fight against Covid-19”. It covers two articles written for Volume 22, Issue 1 – Winter 2020/21 of the Drug Discovery World Magazine. The first article is a case study titled “New technology in COVID research may accelerate vaccines”, and the second is called…
 
John Couse, Vice President of Scientific Services at Taconic Biosciences discusses the benefits of a robust colony management solution/partner in the drug discovery success; how it can enable companies to scale through resource management and create efficiencies. Couse has extensive knowledge of colony managements solutions and outlines the benefit…
 
In this podcast Dr. Joanna Hawryluk discusses automating the cell culture workflow and explains the importance of cell culture workflow in the drug discovery process and how it can be improved thanks to technological advances. Hawryluk talks us through the cell culture workflow and its relevance within the drug discovery process focussing on the ar…
 
Medical devices are an integral part to many procedures and treatments, and last month we started to investigate the vast and innovative world of these types of technologies in a two-part series on The Latest Dose. In part one, our esteemed guests, Dr. Khaudeja Bano, the executive medical director of combination product safety, global patient safet…
 
This episode covers two narrated articles written for DDW and is read aloud by Megan Thomas, both of which were published in Volume 22, Issue 1 – Winter 2020/21 of Drug Discovery World. The first article is titled, “Streamlining gene therapy manufacturing will help products reach more patients”, and was written by Akash Bhattacharya, the Senior App…
 
Digital transformations are having wide-ranging and profound impacts within life sciences, creating both opportunities and challenges. One of those challenges is adopting new software systems to drive the transformations. A team from Novartis Institutes of BioMedical Research (NIBR) recognised the need to ensure a good user experience for their in …
 
From bandaging a sprained ankle and diagnosing HIV/AIDS, to implanting an artificial hip and monitoring your heart, medical devices are an integral part to many medical procedures and treatments. There is a lot to unpack when it comes to medical devices, so we’ve invited industry leaders Dr. Khaudeja Bano, the executive medical director of combinat…
 
This is the latest episode of the free DDW podcast, “Paving the way for optimum drug discovery”. It covers two narrated articles written for Volume 22, Issue 1 – Winter 2020/21 Of DDW and they are read aloud by Megan Thomas. These articles are titled: “In vitro models for assessing drug toxicity: new approaches and development” and “Accelerating as…
 
Mathur talks about Twist’s antibody expertise, drawing on the company’s experience and looking at the importance of collaboration. The company has created some successful partnerships and she explains what these look like, why they have been fruitful, and how they have enabled Twist to use its capabilities to maximum effect. Listen now to hear Math…
 
Aydogdu talks us through how the accurate and quantitative analysis of product purity is a fundamental component of effective development of a biotherapeutic protein. But without consistent techniques and high-quality, reproducible results, it is difficult to precisely assess the product’s efficacy and/or safety, potentially delaying, even jeopardi…
 
The clinical research ecosystem has undergone an evolution over the past 18 months, and many want it to continue. To help set the industry on a solid path forward, ICH has created guidelines that provide direction on behaviors and actions to take. Recently, a specific set of these guidelines, ICH E6 Revision 3 and E8 Revision 1, have been referred …
 
Mälarstig is currently responsible for developing and applying strategies for new drug targets and precision medicine. He has extensive experience working in international academic consortia and public–private partnerships such as the SCALLOP consortium. In this podcast he outlines the role of pQTLs in the drug discovery process and the growing imp…
 
Today's episode will focus on the topic of using genomics to accelerate drug development. Our host is Tõnu Esko, BC Platforms SAB Chairman and Vice Director of the Institute of Genomics University of Tartu, where he also holds a Professor of Human Genomics position. He is head of the Estonian Biobank Innovation Center and focuses on public private …
 
Aboard the HMS Salisbury of Britain’s Royal Navy on May 20th, 1747, surgeon James Lind performed what is often considered to be the first randomized clinical trial. Now, every May 20th, International Clinical Trials Day gives us a well-deserved occasion to honor and thank both the professionals and patients who make clinical research possible. It a…
 
The latest episode of the free DDW podcast, “Precision medicine in the era of artificial intelligence”, covers one narrated article of the same title written for DDW and read aloud by Megan Thomas. It was written by Dr Lofti Chouchane and Dr Javaid Sheikh. Dr Chouchane is a professor in the departments of genetic medicine, and microbiology and immu…
 
Today's podcast will focus on the topic of accelerated insights from data for preventative health innovation. The podcast sheds light on industry challenges and expectations as well as innovative approaches to collaboration. This discussion is led by Tõnu Esko, BC Platforms SAB Chairman and Vice Director of the Institute of Genomics University of T…
 
Today's podcast will focus on the topic of the journey to a safe and secure global data access. This podcast sheds light on industry challenges and expectations, as well as innovative approaches to collaboration. The discussion is led by Tõnu Esko, BC Platforms Scientific Advisory Board Chairman, and Vice Director of the Institute of Genomics at th…
 
The latest DDW Sitting Down With podcast features Raj Indupuri, CEO of eClinical Solutions and he talks to us about clinical trials. Listen to find out why Idupuri believes ‘data is the new fuel that will drive human progress’, the effect of Covid-19 on clinical trials and what the sector can learn from the pandemic to make it better prepared for a…
 
As a methodology that’s generally been underutilized in the past, the pandemic has brought telemedicine to the forefront as a way for doctors to care for their patients, without them having to come into an office or site. But how exactly is it being used in medicine and clinical research today, and will it still be widely used after the pandemic en…
 
Today's episode will focus on the topic of real world data access for label expansion. We are holding an open discussion with a few key leaders on how real world data can be applied in drug development to enhance research and accelerate discoveries. This podcast sheds light on industry challenges and expectations, as well as innovative approaches t…
 
Welcome to the BC Platforms Podcast! BC Platforms is the global leader in providing a powerful data discovery and analytics platform, as well as data science solutions for personalized health care. BC Platforms enables cross-functional collaboration with our global federated network of data partners. This episode is an open discussion with three ke…
 
Welcome to the first episode of the BC Platforms podcast! BC Platforms is the global leader in providing a powerful data discovery and analytics platform, as well as data science solutions for personalized health care. BC Platforms enables cross-functional collaboration with our global federated network of data partners. In today’s episode we are d…
 
This DDW podcast features Dr Hongshan Li, Applications Manager, Sartorius, discussing advances in cell and protein analysis for virology research. This episode examines virology research - what’s currently happening in the sector and how new advances in technology are helping push forward innovation and drug development. With COVID-19 playing such …
 
This narrated article is called “Why flow cytometry in drug discovery is a real life-saver”, in which Roy, Global Product Manager at Miltenyi Biotec, outlines the benefits of flow cytometry, offering case study examples for its use. Capable of boasting high-throughput, accurate, multiparameter and highly reproducible results, it’s time for drug dis…
 
This is the latest episode of the free DDW podcast, titled Vaccine innovation in the age of Covid-19. It covers two narrated articles written for DDW and read aloud by Megan Thomas. These articles are titled: “Vaccine innovation in the age of Covid-19 & beyond” and “Creating vaccines: Why we should be celebrating the life of the researcher”. The fi…
 
Recently, Covance announced that they are transforming to a fully decentralized CRO – an exciting step in the life sciences industry. In this episode, Kathy speaks with Covance’s Director of Decentralized Trials, Jane Myles, and Vice President and Head of Decentralized Trials, Bola Oyegunwa, about how they’re driving the implementation of decentral…
 
This DDW Sitting Down With episode features Guy Goldberg, Chief Business Officer of RedHill Biopharma. In this episode - With vaccines taking centre stage how critical is the part therapeutics have to play in the pandemic? - Goldberg talks us through Covid-19 therapeutics and their role in the pandemic. Goldberg shares his market insight, the benef…
 
Clinical Trial Transformation Initiative (CTTI) announced on January 25, 2021, a new vision for clinical trial ecosystem and beyond, called Transforming Trials 2030. The pandemic has changed the way we perform clinical research, and many constituents have implemented new and efficient solutions, systems, and processes to conduct trials. CTTI member…
 
Today's episode is titled The potential of metabolomics & COVID-19 Vaccine Development, and covers 2 articles taken from the most recent Fall issue of DDW. These articles are titled: Why metabolomics has the potential to transform diagnosis and treatment. & COVID-19 Vaccine Development: dethroning evil King Coronovirus These articles were firstly b…
 
Today's episode is titled: The power of precision and the potential of human tissue chips, and covers 2 articles taken from the most recent issue of DDW. These articles are titled: The power of precision to keep biologics effective and safe & Why we should be interested in human tissue chips These articles were written by Dr Mark Lies, Global Busin…
 
The pandemic has created a lot of disruption in clinical trials, but not all of it has been negative. From accelerating the adoption of decentralized trials and speeding up the delivery of vaccines, to telemedicine and mHealth playing bigger roles in patients’ lives, opportunities have emerged to help us rediscover and recalibrate the way we perfor…
 
Today's episode on the topic of The Business Side of Drug Discovery, covers 3 articles taken from the most recent Fall issue of DDW. These articles are titled: Building the foundations for post COVID-19 R&D, Opportunity Knocks: Why compound screening libraries are worth the investment, and How to achieve data driven R&D at speed These articles were…
 
Today's episode on the topic of Innovation and Opportunity in Drug Discovery, covers 3 articles taken from the most recent Fall issue of DDW. These articles are titled: Japanese drug development: Where is the innovation, Where are the opportunities in global drug discovery, and New for Old: The value behind drug repurposing. These articles were wri…
 
The Pistoia Alliance has developed a research paper which sets out to consider what the life science, biopharma R&D and healthcare ecosystem might look like in 2030, in particular how the increasing adoption and sophistication of technology will affect companies and patients alike. This article is the second part of a two-part series based on that …
 
Research shows that animals can improve the mental, physical, and emotional wellbeing of their human companions. From this strong bond comes the concept of therapy animals, or in this case, therapy dogs. But what is a therapy dog, and how are they being used today? In this episode, Kathy speaks with Children's Hospital Los Angeles and the Alliance …
 
This article is the first in a two-part series based on The Pistoia Alliance report. Written in retrospect from the world as it is in 2030, it looks at how healthcare has changed in the intervening decade, covering the socio-economic and political evolutions that have happened, the subsequent effects on population health and the innovative technolo…
 
Since 2017 we have seen the slow and steady adoption of User Experience (UX) within the life sciences. User Experience is an evidence-based design process that centres on the behaviours and needs of users. The clear benefits of UX offered in the retail and consumer sectors have been slow to percolate to other more complex sectors such as the life s…
 
Non-alcoholic fatty liver disease (NAFLD) has quietly become one of the most common causes of chronic liver disease in the modern world. If this prevalence is allowed to continue the economic and clinical burden will reach a staggering level. Non-alcoholic fatty liver disease (NAFLD) consists of a complex combination of liver maladies, ranging from…
 
This article will describe, with examples, how understanding the likely mechanisms of false positives in advance of screening informs the design of the hit triage, thus increasing the likelihood of discovering optimisable chemical matter and avoiding costly wasting of resource. We describe the use of a bespoke ‘Robustness Set’ of nuisance compounds…
 
Every year, the brightest minds in pharmaceuticals and clinical innovation put on their best black-tie attire for the life science industry’s biggest event, the Prix Galien. In this episode, you’ll learn about the history of the Prix Galien Awards, why it is considered the “Nobel Prize” for pharmaceutical research and development, and find out the …
 
The pandemic heavily disrupted clinical trials, pushing us to rethink how we conduct clinical research. In this episode, Kathy invites Casey Orvin, SVP of pharmaceutics relationships at StudyKIK and honorary president of SCRS to talk about the future of decentralized trials and remote visits from the patient and site perspective.…
 
The emergence of SARS-CoV-2 virus and the disease it causes, COVID-19, have fuelled significant shifts in preclinical research across the globe. Amid the worldwide health emergency created by high infection rates, rapid transmission spread and relatively high mortality rates, researchers are under pressure to understand the disease’s pathogenesis, …
 
Cryo-electron microscopy (cryo-EM), a powerful biophysical technique that can analyse molecular assemblies, is changing the paradigm in structure-based drug design. As targets become more challenging, solving structures of drug target molecules or biologics becomes increasingly difficult. Cryo-EM empowers drug discovery teams to take advantage of r…
 
In this episode, we discuss the oxymoronic proposition of a Virtual Pharmaceutical Company (VPC) and the typical adopted business model, as well as provide examples of such companies currently trying to undertake this adventurous task. The vagaries and complexities of bringing a therapeutic drug to market through the Drug Discovery and Development …
 
In episode seven of The Latest Dose, our host Kathy Vandebelt invites two of Oracle’s safety experts, Vice President of Safety Product Strategy, Bruce Palsulich, and Senior Director of Safety Strategy, Michael Braun-Boghos, to explore areas in pharmacovigilance where AI, automation, and touchless case processing are having a significant and positiv…
 
Mitigation of COVID-19 pandemic requires a combination of effective epidemiological policies and the discovery/development of powerful drugs against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes this disease. This two part article series examines the major initiatives being explored at the public policy level to conta…
 
Mitigation of COVID-19 pandemic requires a combination of effective epidemiological policies and the discovery/development of powerful drugs against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes this disease. This 2 part episode series examines the major initiatives being explored at the public policy level to contain…
 
The recent outbreak of COVID-19 has highlighted the need for fast and efficient development and production of vaccines for a whole gamut of pathogens, old and new. Microfluidics technologies can be used to accelerate the vaccine development process in a number of ways, not least in the directed evolution of the strains and host organisms used in th…
 
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